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Immunology is in our blood

We use cell cultures, primary tumor samples and mouse models to study the interaction between immune cells and hematopoietic cells in normal and malignant conditions.

Made by Shakked Elias
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Blue Skies

About

Hematopeotic cells have close interaction with immune cells specifically in the bone marrow,
where hematopoietic cells are produced. Previous studies have shown that mature lymphoid
cells can interact with developing hematopoietic cells and affect normal hematopoiesis in the
bone marrow, yet the complete network of such interactions has not been elucidated. Since
mature immune cells can interact with developing hematopoietic cells, they could also
interact with malignant cells (e.g., leukemic cells) residing the bone marrow.

 

The general aim of our lab is to explore the interface between immune cells and
hematopoietic cells in the normal state, in malignancy and in the context of bone marrow
transplantation and Graft vesus Host Disease (GvHD), which is a common complication after
bone marrow transplantation. Our main organ of interest is the bone marrow, where normal
hematopoietic cells are produced, and leukemia is initiated. We are also interested in
improving cellular therapies for malignancies and bone marrow transplantation. In order to
achieve these goals, we use cell cultures, mouse models and bone marrow samples from
patients. The main techniques we utilize are FACS analysis and immunofluorescence.

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Selected publications

Elias S, Sharma R, Schizas M, Valdez I, Rampersaud S, Park SM, Gonzalez-Figueroa P, Li QZ, Hoyos B,Rudensky AY. CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow.  J Exp Med. 2022 Jul 4;219(7). doi: 10.1084/jem.20220047. Epub
2022 Jun 7. PubMed PMID: 35670812; PubMed Central PMCID: PMC9178519.

Elias S, Kol I, Kahlon S, Amore R, Zeibak M, Mevorach D, Elchalal U, Zelig O, Mandelboim O. Anti-RhD antibody therapy modulates human natural killer cell function.  Haematologica. 2021 Jul 1;106(7):1846-1856. doi: 10.3324/haematol. 2019.238097. PubMed PMID: 32467141; PubMed Central PMCID: PMC8252960.

Elias S, Rudensky AY. Therapeutic use of regulatory T cells for graft-versus-host disease. Br J
Haematol. 2019 Oct;187(1):25-38. doi: 10.1111/bjh.16157. Epub 2019 Aug 16. Review. PubMed PMID: 31418827; PubMed Central PMCID: PMC8054701.

 

Elias S, Kahlon S, Duev-Cohen A, Mandelboim O. A BW Reporter System for Studying Receptor-Ligand Interactions. J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58685. PubMed PMID: 30663643.

 

Kahlon S, Shreibman D, Unger T, Ben-Yehuda D, Elias S. The oncogenic fusion protein CBFB-SMMHC
downregulates CD48 to evade NK cell recognition
.
Blood Cancer J. 2018 May 24;8(5):48. doi:
10.1038/s41408-018-0082-7. PubMed PMID: 29795444; PubMed Central PMCID: PMC5968028.

Elias S, Kahlon S, Kotzur R, Kaynan N, Mandelboim O. Obinutuzumab activates FcγRI more potently
than other anti-CD20 antibodies in chronic lymphocytic leukemia (CLL)
.
Oncoimmunology. 2018;7(6):e1428158. doi: 10.1080/2162402X.2018.1428158. eCollection 2018. PubMed PMID: 29872553; PubMed Central PMCID: PMC5980409.

 

Elias S, Yamin R, Golomb L, Tsukerman P, Stanietsky-Kaynan N, Ben-Yehuda D, Mandelboim O.
Immune evasion by oncogenic proteins of acute myeloid leukemia. Blood. 2014 Mar 6;123(10):1535-
43. doi: 10.1182/blood-2013-09-526590. Epub 2014 Jan 21. PubMed PMID: 24449212; PubMed Central PMCID: PMC3981677.

 

Elias S, Mandelboim O. Battle of the midgets: innate microRNA networking. RNA Biol. 2012
Jun;9(6):792-8. doi: 10.4161/rna.19717. Epub 2012 May 23. Review. PubMed PMID: 22617882.

 

Mitelman R, Rosin B, Zadka H, Slovik M, Heimer G, Ritov Y, Bergman H, Elias S. Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease. Front Syst Neurosci. 2011;5:54. doi: 10.3389/fnsys.2011.00054.eCollection 2011. PubMed PMID: 21747760; PubMed Central PMCID: PMC3129135.

 

Elias S, Ritov Y, Bergman H. Balance of increases and decreases in firing rate of the spontaneous
activity of basal ganglia high-frequency discharge neurons.
J Neurophysiol. 2008 Dec;100(6):3086-
104. doi: 10.1152/jn.90714.2008. Epub 2008 Oct 8. PubMed PMID: 18842958.

 

Elias S, Joshua M, Goldberg JA, Heimer G, Arkadir D, Morris G, Bergman H. Statistical properties of
pauses of the high-frequency discharge neurons in the external segment of the globus pallidus
. J
Neurosci. 2007 Mar 7;27(10):2525-38. doi: 10.1523/JNEUROSCI.4156-06.2007. PubMed PMID:
17344390; PubMed Central PMCID: PMC6672489.

For complete list of publications see  https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/

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